ISSN:
0570-0833
Keywords:
Tetracyclines
;
Antibiotics
;
Structure-activity relationships
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Tetracycline antibiotics continue to play an important role in human and veterinary medicine and in animal nutrition. The classical tetracyclines obtained by fermentation have been supplemented by products of partial synthesis which provide, in particular, the advantages of better pharmacokinetic properties and greater tolerance. Following a brief review of older work, the present article describes partial and total syntheses of tetracyclines, the influence of electronic, steric, and lipophilic factors and of complex formation on biological activity. The inhibition of biochemical systems invoked in interpretation of the mode of action of tetracyclines and problems involved in the development of resistance are discussed.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.197507211
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