ISSN:
1432-2072
Keywords:
Sleep
;
Methadone
;
Sustained ingestion
;
Monkey
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Methadone HCl was administered daily to four stump-tailed macaques. The animals' sleep was periodically examined throughout a year of methadone maintenance and, in two animals, during eight months of withdrawal. REM sleep was substantially decreased by methadone treatment and gradually returned to predrug values over a 6-to 8-month period of maintenance. Measures of non-REM sleep and awakenings showed similar disruption with no return to predrug values. These changes were not correlated with alterations in plasma-methadone concentrations. REM sleep rebound occurred temporarily upon drug with-drawal in two animals, but no consistent sleep disruption was apparent during the subsequent eight months. Contrary to some suggestions, therefore, tolerance to the sleep-disruptive effects of the drug may be specific and incomplete, and extended REM rebound upon withdrawal is not a universal response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429175
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