ISSN:
1573-2592
Keywords:
T cells forming autorosettes
;
T cells not forming autorosettes
;
suppressor effect
;
amplifier effect
;
neuraminidase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract When human T cells were treated with neuraminidase fromVibrio cholerae, the capacity of T cells to form rosettes with autologous erythrocytes was markedly enhanced. The neuraminidase-treated T cells were separated with autologous erythrocytes into autorosetting and nonrosetting cell populations, and these two populations examined for their reactivity to mitogens and B cells and for their regulatory activities. Autorosetting T cells proliferated poorly in response to mitogens and autologous and allogeneic B cells; these cells were particularly enriched for cells capable of becoming concanavalin A-induced suppressor cells. Nonrosetting T cells capable of most actively proliferating in response to the mitogens and the B cells failed to exhibit such suppressor function after concanavalin A activation. Coculture experiments between autorosetting and nonrosetting cells further demonstrated that the nonrosetting T cells were able to potentiate the proliferation of the autorosetting T cells with concomitant expression of the suppressor properties.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00915974
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