ISSN:
1573-8221
Keywords:
thymus factor
;
thymectomy
;
T-lymphocytes
;
antibody-formation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In experiments on thymectomized adult CBA mice the effect of a homogeneous factor of polypeptide nature from the thymus, with mol. wt. about 5000 (thymarin-III) on the cellular and humoral indices of immunity was studied in animals. Thymectomy in animals was shown to sharply reduce the number of T-cells in the spleen. Correspondingly, the ability of the mice to produce both IgM- and IgG-antibody-forming cells and humoral antibodies against a thymus-dependent antigen (sheep's red blood cells) was sharply inhibited in the mice. Subcutaneous injection of thymarin-III in a dose of 1 μg/kg into the animals daily for 7 days completely restored the T-cell population of the spleen and restored the normal immunologic reactivity of the animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00801303
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