ISSN:
1432-2013
Keywords:
Key words Transducisome
;
INAD signaling complex TRP
;
TRPL
;
PDZ domains
;
phototransduction Drosophila
;
Calliphora
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two types of ion channels, TRP and TRPL, are activated upon light-absorption in rhabdomeral photo-receptor membranes of fly compound eyes. Whereas TRP is associated with other signaling proteins into a multiprotein complex (transducisome), the molecular organization of TRPL is discussed controversely. We analysed the TRPL content of blowfly rhabdomeral membranes and investigated by co-immunoprecipitation studies whether or not TRPL is part of the transducisome. Compared to TRP there are at least ten times less TRPL molecules present in the rhabdomeral membrane. A small fraction of the total TRPL present co-immunoprecipitates with other proteins of the transducisome and vice versa. Our data suggest that a significant fraction of TRPL is not incorporated into the transducisome. This fraction may either form independent ion channels or bind to the transducisome transiently.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004240000138
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