ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Micellar electrokinetic capillary electrophoresis
;
Tetrahydrocarbazole derivatives
;
β-Cyclodextrin
;
Taurodeoxycholate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary 2,3,4,6-tetra-O-acetyl-β-D-glucopranosyl isothiocyanate derivatives of a number of basic compounds, containing one chiral center, have been prepared. The indirect resolution of enantiomers was achieved with a high separation efficiency by capillary electrophoresis, using a sodium taurodeoxycholate/β-cyclodextrin system. This methodology was found to be superior to the resolution of the same derivatives by reversed phase HPLC analysis. A possible mechanism for stereoselectivity is described.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02268292
Permalink