ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Factors contributing to hypotension during hemodialysis (1996)

Flynn, James J.

Springer

Geriatric nephrology and urology 6 (1996), S. 99-104

add to mindlist on the mindlist

Details

ISSN: 1573-7306

Keywords: hemodialysis hypotension ; chronic hemodialysis ; diabetic nephropathy ; midodrine

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Background The characteristics of patients receiving chronic hemodialysis in the United States has continuously changed over the past three decades. Today the patients are older, and the incidence of diabetic nephropathy has markedly increased. Hypotension during hemodialysis is the most common and bothersome complication of chronic hemodialysis. The demographics of those patients who experience hypotension during dialysis has not been previously identified. Methods The change in systolic pressure during hemodialysis was reviewed for ten consecutive hemodialysis treatments in 134 patients in a single hospital-based unit. For the past four years, those patients who have had symptoms during their hypotensive episodes associated with hemodialysis have been under continuous therapy with midodrine. Results In the present study, the overall incidence of patients experiencing decreases of, at least, 40 mmHg systolic pressure, in over 50% of their treatments, is 63%. The incidence of patients having symptoms from hypotension during hemodialysis is 25%. Analysis of the dialysis population shows that the age of the patients is a primary factor leading to hypotension. Diabetic nephropathy is identified as a second risk factor for hypotension. However, the incidence in the asymptomatic group versus the symptomatic group was not statistically significant. In the group of patients (25%) who have hypotension during hemodialysis with clinical symptoms, all had hypertension requiring therapy prior to initiating hemodialysis. Hypertension may be a predisposing factor to the development of hypotension. Females tended to have more hypotension during dialysis than males. Conclusions As a result of the increasing age of patients receiving hemodialysis and the increasing incidence of diabetic nephropathy, hypotension will become an even greater problem in the future.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00451113

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Mouse transition protein 1 is translationally regulated during the postmeiotic stages of spermatogenesis (1989)

Yelick, Pamela C. ; Kwon, Yunhee Kim ; Flynn, James F. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Molecular Reproduction and Development 1 (1989), S. 193-200

add to mindlist on the mindlist

Details

ISSN: 1040-452X

Keywords: Gene expression ; Testis ; Protamine ; DNA binding proteins ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: Transition protein 1 (TP1) is a small basic nuclear protein that functions in chromatin condensation during spermatogenesis in mammals. Here, recently identified cDNA clones encoding mouse transition protein 1(mTP1) were used to characterize the expression of the mTP1 mRNA during spermatogenesis. Southern blot analysis demonstrates that there is a single copy of the gene for transition protein 1 in the mouse genome. Northern blot analysis demonstrates that mTP1 mRNA is a polyadenylated mRNA approximately 600 bases long, which is first detected at the round spermatid stage of spermatogenesis. mTP1 mRNA is not detectable in poly(A)+ RNAs isolated from mouse brain, kidney, liver, or thigh muscle. mTP1 mRNA is translationally regulated in that it is first detected in round spermatids, but no protein product is detectable until approximately 3 days later in elongating spermatids. In total cellular RNA isolated from stages in which mTP1 is synthesized, the mTP1 mRNA is present as a heterogeneous class of mRNAs that vary in size from about 480 to 600 bases. The shortened, heterogeneous mTP1 mRNAs are found in the polysome region of sucrose gradients, while the longer, more homogeneous mTP1 mRNAs are present in the postmonosomal fractions.

Additional Material: 5 Ill.