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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 340 (1973), S. 89-99 
    ISSN: 1432-2013
    Keywords: Panting ; Hypoxic Response ; Control of Respiration ; Thermoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ventilatory response to isocapnic hypoxia was studied in anesthetized dogs during normothermia and thermally induced panting. In the normothermic dog, minute ventilation (E), tidal volume (V T) and respiratory frequency (f) did not vary significantly with changes ofPaO2 above 80–90 mm Hg. Below this value, these three parameters increased substantially with progressively decreasingPaO2. During panting the ventilatory response was triphasic: 1. withPaO2 values above 90 mm Hg ventilation remained unaffected; 2. whenPaO2 progressively decreased from 90 to 45 mm Hg, ventilation increased significantly over the levels of ventilation reached in response to heat alone; 3. withPaO2 under 45 mm Hg ventilation abruptly decreased as compared to the second phase of the response.V T increased significantly during the second and third segments as compared to the first. Respiratory frequency progressively decreased whenPaO2 was under 60 mm Hg Isocapnic hypoxia suppressed thermally induced panting (tachypnea) but led to reduction of evaporative heat loss only at the lowest values ofPaO2. Apparently, in the panting animal chemical control of respiration is set aside by the thermoregulatory control. However, chemical regulation of respiration may set aside the normal respiratory pattern of thermal polypnea in response to acute chemical stimuli, such as arterial hypoxia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 361 (1975), S. 79-81 
    ISSN: 1432-2013
    Keywords: Cyanide ; Doxapram ; Panting ; Control of respiration ; Thermoregulation ; Peripheral chemoreceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ventilatory responses, blood gases and acid-base status to intravenous injections of KCN and doxapram hydrochloride were studied in anesthetized dogs during normothermia and thermally induced panting. In the normothermic animal, KCN evoked elevation of $$\dot V$$ E (154.7%),V T (70.1%),f (48.3%),PaO2 (12.1%) and pH (0.098 units), whilePaCO2 diminished by 9.7 mm Hg. During panting, KCN infusions resulted in increases of $$\dot V$$ E (24.5%),V T (46.6%),PaO2 (3.9%) and pH (0.034 units), whilef decreased (10.1%). Bolus injections of doxapram during normothermia increased $$\dot V$$ E (32.6%),V T (18.8%) andf (17.1%). During panting $$\dot V$$ E ,V T andf increased by 18.0%, 18.2% and 1.5%, respectively. These results demonstrate that the peripheral (arterial) chemoreceptors preserve the capacity to react to acute chemical stimuli in animals in which the thermal stimuli override the normal chemical control of respiration in order to control body temperature, and that this reaction contributes to the integrated respiratory drive.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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