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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 234 (1984), S. 181-188 
    ISSN: 1432-0711
    Keywords: Proteinases ; Proteinase inhibitor ; Uterus ; Carcinoma ; Leiomyoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activities of an acid proteinase, of an alkaline proteinase, of a lysine aminopeptidase and of a proteinase B inhibitor were measured in benign and malignant tumors of the human uterus. In carcinomas of the corpus uteri the activity of the acid proteinase (cathepsin D) was increased compared to normal endometrium. This could probably be the result of cell destruction within the tumor. In leiomyomas of the uterus the activities of the alkaline proteinase, of the lysine aminopeptidase, and of the proteinase inhibitor were decreased compared to the normal myometrium. These results suggest that a decrease in the rate of degradation of myofibrillar proteins relative to the rate of protein synthesis may be responsible for the growth of myomas.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 222 (1977), S. 231-238 
    ISSN: 1432-0711
    Keywords: Uterus ; Involution ; Hypotrophy ; Hypoplasia ; Hyperinvolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Beim postpartalen Rattenuterus wurden während 10 Tagen nach dem Wurf Uterusgewicht, lösliches Protein und DNS gemessen. Uterusgewicht und Proteingehalt des Gesamtuterus fielen nach einer Latenz von 48 Std in ähnlichem Verlauf auf 1/12 des Ausgangswertes ab, während der DNS-Gehalt sich nicht signifikant änderte. Der Anteil der Hypoplasie an der Gewichtsreduktion betrug maximal 20%, während mindestens 80% des Gewebeschwundes durch Hypotrophie zustande kamen. Die Proteinmenge pro Zellkern (mg Protein/mg DNS) fiel innerhalb von 10 Tagen um 85% ab. Bei nicht trächtigen Vergleichstieren lagen Uterusgewicht und Proteinmenge pro Zellkern über den entsprechenden Werten bei Tieren am 10. Tag post partum. Die Proteinkonzentration des Gewebes (mg Protein/g Feuchtgewicht) war dagegen niedriger. Diese Hyperinvolution am 10. Tag wird als Folge des gegenüber Normaltieren niedrigeren Östrogenspiegels der lactierenden Tiere erklärt.
    Notes: Summary In post partum rat uteri, the wet weight, the soluble protein and the DNA content were measured for ten days following delivery. After a lag period of 48 h, the weight and protein content of whole uteri decreased in parallel to one twelfth of the initial values. The DNA content did not change significantly. Hypoplasia contributed not more than 20% to the weight loss, so that at least 80% of the loss was due to hypotrophy. The protein content per cell nucleus (mg protein/mg DNA) decreased by 85% within 10 days. In non-pregnant control animals, uterus weight and protein content per cell nucleus were greater than those of animals measured on the tenth post partum day. In contrast, the protein concentration of the tissue (mg protein/g wet weight) was lower in the control group. It is suggested that this hyperinvolution is caused by the low estrogen levels of the lactating animals.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 110 (1985), S. 141-144 
    ISSN: 1432-1335
    Keywords: Carinoma ; Tissue heterogeneity ; Estrogen receptor ; Progesterone receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Biochemical determination of hormone receptors in carcinomas is influenced by the potential heterogeneity of the tissue samples. In order to check this, samples of 16 breast cancers were divided into 6 segments. These segments were alternately examined for their ratio of tumor tissue to connective tissue (“percentage of carcinoma”) or for the content of estrogen and progesterone receptors. Only 3 of the tumors were homogeneous, and 9 of the heterogeneous tissues had hormone receptors. The segment with the maximum “percentage of carcinoma” was adjacent to that with the peak value of hormone receptors in all but 1 tissue. The same applied to the minima. The maximum and minimum values of estrogen and progesterone receptors were located within the same segment in all but one tissue sample. The results demonstrated that biochemical assay of hormone receptors is reliable. A reduction of the sample volume does not enhance the precision of the receptor assay, since it increases the possibility of a false negative result.
    Type of Medium: Electronic Resource
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