ISSN:
0009-2940
Keywords:
Indoles, 2-aryl-
;
Titanium graphite
;
Zindoxifene
;
Tumor-growth inhibitors
;
Alkylidenation, intramolecular
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Highly reactive titanium on graphite is used to reductively cyclize electron-rich acylamino carbonyl compounds 7, 8, 12, 14, and 16 to the corresponding indole derivatives 9, 10, 13, 15, and 17. Compound 9b is a known precursor of the mammary tumor-inhibiting compound zindoxifene (2). The other products are new analogues of this anticancer drug, exhibiting the substitution pattern previously recognized to be essential for high pharmacological activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19941270624
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