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  • 1
    Electronic Resource
    Electronic Resource
    Development and loss of tolerance to morphine in the rat (1982)
    Springer
    Psychopharmacology 78 (1982), S. 234-238 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Tolerance ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of a differential tolerance to morphine was investigated with respect to the mean effective dose, the threshold dose of tolerance, the degree of tolerance after a fixed dose, and the speed of tolerance loss. The mean effective doses, the threshold doses of tolerance, and the degree of tolerance differed considerably from effect to effect, whereas in all tests tolerance loss remained the same. The mean effective doses were not correlated to threshold doses of tolerance, degree of tolerance, or to the loss of tolerance, but a strong correlation exists between threshold doses of tolerance and degree of tolerance to all effects measured. Consequences of these results upon current theories of tolerance are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428157
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Quantitative assessment of tolerance to and dependence on morphine in mice (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 297 (1977), S. 53-60 
    Details
    ISSN: 1432-1912
    Keywords: Morphine ; Tolerance ; Dependence ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Tolerance to morphine-induced analgesia (hot plate and acetic acid whrithing test), hypothermia and lethality can be quantified in mice by measuring the degree of parallel shifts of semilog. dose-response relationships induced by repeated opioid administration. 2. A similar procedure can be used for the quantification of naloxone-induced withdrawal as an indicator of dependence. 3. The intensity of tolerance development with respect to time of administration and dosage of morphine varies with the test procedure. It is closely parallel, however, in both analgesic tests during acquisition of tolerance. 4. Log-log-linear relationships exist between tolerance in analgesic tests and physical dependence as determined by naloxone-induced withdrawal. 5. The minimum tolerance-inducing dose of morphine in different tests could not be correlated to the ED50's in these tests. 6. Chronic opiate treatment leads to a decrease or an increase in motility response to morphine, depending on the time that has elapsed after the last morphine administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508810
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The effect of chronic self-administration of d-amphetamine on food intake, locomotor activity, and C14-leucine incorporation into cerebral cortex protein (1976)
    Springer
    Psychopharmacology 45 (1976), S. 267-270 
    Details
    ISSN: 1432-2072
    Keywords: d-Amphetamine ; Tolerance ; Hyperactivity ; Cerebral protein synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats had free access to 0.02% d-amphetamine solution instead of water for 23 days. The daily amphetamine consumption was found to increase from 16 mg/kg on day 1 up to 47 mg/kg on day 23. Tolerance to the anorexic effect of the drug was apparent on day 11. The initial depression in body weight persisted throughout the experiment. The hyperactivity of rats remained at the same level despite the daily increase in amphetamine intake. The incorporation of C14-leucine into cerebral cortex proteins was initially increased and returned to control level after 2 weeks of treatment. No direct correlation between hyperactivity and brain cortex protein synthesis was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421138
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The development of tolerance to morphine in the rat (1977)
    Springer
    Psychopharmacology 54 (1977), S. 197-201 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Tolerance ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tolerance to various effects of morphine in the rat can be quantified by means of a shift of semilogarithmic dose-response curves. Tolerance to analgesia (hot plate, acetic acid writhing), catalepsy, and the tilted plane develops in a closely similar manner. Also, the stimulating effects of about 1 mg/kg morphine-HCl tested in an open-field procedure are somewhat less pronounced in chronically treated rats than in naive ones. There is no correlation between tolerance development and the acute ED50 of different tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426780
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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