ISSN:
1432-203X
Keywords:
Tripterygium
;
Oleanane
;
Triterpene
;
Elicitation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Treatment of cell suspension cultures of Tripterygium wilfordii with an autoclaved Botrytis sp. homogenate rapidly increased the synthesis of a family of oleanane and friedelane triterpenes, including the antiinflammatory oleanane triterpene 3β,22α-dihydroxyolean-12-en-29-oic acid. This compound exceeded 30 mg · l−1 in 13 day elicitations with 12 l bioreactors, in contrast to control levels of less than 5 mg · l−1. Cell cultures treated with the fungal elicitor provided higher triterpene yields in less time than cultures in a diterpene production medium or whole plants. Elicited production has been developed for commercial application in light of the successful treatment of rheumatoid arthritis with Tripterygium extracts.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00237435
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