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  • Ty elements  (1)
  • Ubiquitination  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Characterization of novel rad6/ubc2 ubiquitin-conjugating enzyme mutants in yeast (2000)
    Springer
    Current genetics 37 (2000), S. 221-233 
    Details
    ISSN: 1432-0983
    Schlagwort(e): Key Words Rad6 ; Ubiquitination ; Silencing ; Yeast
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Null mutations in the RAD6/UBC2 gene encoding an E2 ubiquitin-conjugating enzyme cause deficiencies in DNA repair, N-end-rule protein degradation, sporulation and telomeric silencing, and alter the preferred integration positions for Ty1 retrotransposons. Here we selected for mutants of RAD6 that cause a release of telomeric silencing. Some alleles retained nearly wild-type ability for sporulation, DNA repair and the degradation of proteins. Alteration in Ty1 integration-site bias accompanied some of these alleles. The possibility that some mutations specifically affect binding of an unknown protein that works with Rad6 in its silencing role, but is not required for DNA repair or N-end-rule activity, is discussed in terms of the Rad6 crystal structure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002940050523
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    The same configuration of Ty elements promotes different types and frequencies of rearrangements in different yeast strains (1988)
    Springer
    Molecular genetics and genomics 211 (1988), S. 272-281 
    Details
    ISSN: 1617-4623
    Schlagwort(e): Yeast ; Ty elements ; Recombination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary We examined Ty-mediated genomic rearrangements in three related mitotically dividing haploid yeast strains having the same configuration of Ty elements in the CYC1-sup4 interval of chromosome X. Surprisingly, quite different types and frequencies of rearrangements were found in the three strains. In one strain we found only Ty-mediated deletions, which occurred with a frequency of about 1×10-6. Another strain yielded similar deletions, but approximately one-third of these were accompanied by adjacent Ty-mediated inversions. A third strain was found to have an extremely high rate of inversion/reinversion between two of the three Ty elements. This rate was conservatively estimated to be 1.4±0.2×10-2 per cell per generation, which is at least 2 orders of magnitude higher than previously reported values for Ty-mediated rearrangements. These data provide evidence that local regions of the genome can, in some cases, be much more fluid than had been previously believed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00330604
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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