ISSN:
1432-1335
Keywords:
Tumor promoter
;
Type D primate retroviruses
;
Mason-Pfizer monkey virus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate (TPA) increases by severalfold the synthesis of Mason-Pfizer monkey virus (MPMV), a type D retrovirus, when the virus is growing in human embryo kidney (HEK) cells. The effect is transient and paralleled by a striking morphological alteration of the cells. The optimal TPA concentration for stimulation is 5 ng·ml-1. Contrary to infected HEK cells, TPA induces at similar concentrations neither stimulation of MPMV synthesis nor altered morphology in persistently MPMV-infected cells of the continuous human tumor cell line A 204.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00411347
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