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  • 1
    Electronic Resource
    Electronic Resource
    Effect of AF64A on the cholinergic systems of the retina and optic tectum of goldfish (1988)
    Springer
    Experimental brain research 70 (1988), S. 455-462 
    Details
    ISSN: 1432-1106
    Keywords: Cholinergic toxin ; Retina ; Optic tectum ; ChAT ; Ultrastructure ; Goldfish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary AF64A, a presumed selective cholinergic neurotoxin has been used to study the effect on cholinergic systems of the goldfish retina and optic tectum. Toxin injection in the vitreum and in the optic tectum caused a selective decrease of choline acetyltransferase activity in both areas, while no significant decrease of glutamate decarboxylase and D-3H aspartate uptake were observed at different times after the injections. The effect was particularly dramatic in the retina of long term-injected animals, where choline acetyltransferase dropped to practically zero level. The ultrastructural analysis showed selective degeneration of some neurons in the amacrine and ganglion cell layer of the retina as well as of synaptic terminals and neuronal cell bodies in the optic tectum. The results favour a selective cholinotoxicity of AF64A in fish nerve tissue at doses substantially higher than those found to have additional unselective effects in mammals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00247593
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Modification of ultrastructural and neurochemical parameters in synaptosomes of the retino-deprived goldfish optic tectum (1986)
    Springer
    Experimental brain research 62 (1986), S. 560-566 
    Details
    ISSN: 1432-1106
    Keywords: Optic tectum ; Neurotransmitters ; Cholinergic markers ; Ultrastructure ; Goldfish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurochemical parameters associated with cholinergic and excitatory amino acid transmission, were measured in synaptosomes of the goldfish optic tectum at different times after unilateral eye ablation. Significant decreases in choline acetyltransferase and acetylcholinesterase were measured 12 and 30 days after enucleation. The high affinity choline uptake did not parallel the decrease in cholinergic enzymes. Instead there was a significant increase of the uptake per unit of protein (though not relative to the total number of tectal synaptosomes). No decrease of the high affinity D-3H aspartate uptake was measured in the deafferentated optic tectum. Electron microscopic observations showed a correspondence between the time course of cholinergic enzyme decrease and the degeneration of retinal afferents to the tectum. The present results support the notion that acetylcholine is a better candidate than the excitatory amino acids for a neurotransmitter role in the fish optic tectum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236034
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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