ISSN:
1432-0738
Schlagwort(e):
p-Chloronitrobenzene
;
Urinary metabolites
;
Rat
;
Gas chromatography-mass spectrometry
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Urinary metabolites in rats treated withp-chloronitrobenzene were identified by gas chromatography-mass spectrometry. A single dose of 100 mg/kg body wtp-chloronitrobenzene was administered intraperitoneally to male Sprague-Dawley rats and urine samples were collected from the 8th to 24th hour after the administration. Urinary metabolites were extracted with diethylether at pH 1.0 and pH 10.0 from urine samples hydrolyzed with acid and base and from intact urine samples. Aliquots of the ethereal extracts were injected into a gas chromatograph-mass spectrometer. Nine substances were identified:p-chloroaniline, 2,4-dichloroaniline,p-nitrothiophenol, 2-chloro-5-nitrophenol, 2-amino-5-chlorophenol,p-chloroformanilide, 4-chloro-2-hydroxyacetanilide, a small amount ofp-chloroacetanilide and traces of unchangedp-chloronitrobenzene.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01973503
Permalink
