ISSN:
1434-0879
Keywords:
Urolithiasis
;
Tranexamic acid
;
Fibrinolysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The influence of decreased urinary fibrinolysis on renal stone formation was studied in rats fed on a calculus producing diet. The alteration in the isolated glomerular fibrinolytic activity indicating the amount of urokinase produced has also been investigated using a histochemical fibrin slide technique. The glomerular fibrinolytic activity was significantly enhanced by both tranexamic acid and the dietary treatment. The induced antifibrinolysis resulted in a significantly higher incidence of grossly visible calculi in the renal pelvis and in calcified deposits along the cortico-medullary border of the kidney. The results support the concept that a decline in urinary fibrinolytic activity can lead to the formation of renal stones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00256679
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