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  • 1
    ISSN: 1569-8041
    Keywords: follicular lymphoma ; high-dose therapy ; purging ; randomized trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:The CUP trial was initiated to analyze the value ofhigh-dose therapy and stem-cell transplantation and purging in patients withrelapsed chemosensitive follicular NHL. Patients and methods:After three cycles of chemotherapyresponsive patients were randomized to either three more cycles of the samechemotherapy (C), high-dose therapy followed by autologous unpurged (U) orpurged (P) stem-cell transplantation. Purging was performed using a cocktailof monoclonals. Pretransplant conditioning consisted of cyclophosphamide (60mg/kg × 2) and total body irradiation. Results:Of the 140 patients registered from 26 centers in Europe,89 fulfilled the criteria for randomization (C: 24, U: 33 and P: 32). Reasonsfor failure to randomize were: no response (28), persistent marrowinfiltration (4), patient refusal (7), other (7), no data (5). With thecurrent follow up (median 26 months from randomization) 16 (66%) in Care known to have progressed or relapsed, in contrast to 13 (39%) ofU and 12 (37%) of the P patients (P-value 0.002). Overallsurvival is premature with the current available data. Conclusions:Patients in U and P arms had higherprogression/relapse-free survival rate. There are some suggestions of someimprovement in overall survival rate.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Mechanics of time-dependent materials 2 (1998), S. 371-387 
    ISSN: 1573-2738
    Keywords: composite beam ; crown sensitivity ; elastic-viscoelastic correspondence principle ; head gimbal assembly ; magnetic recording ; thermal bending ; viscoelastic adhesive ; WLF equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The temperature excursions inside a magnetic recording disk drive can be as much as 20 to 60°C. When subjected to these temperature changes, thermal expansion coefficient mismatch between the ceramic slider and the stainless steel suspension causes bending. This thermal bending is mediated by the viscoelastic properties of the polymeric adhesive attaching the slider and the suspension. We employ the elastic-viscoelastic correspondence principle to model thermal bending. We calculate thermal bending up to 30 nm for a high-modulus adhesive and only 0.8 nm for a low-modulus adhesive over typical temperature variations. The low-modulus adhesive exhibited remarkable time-dependent oscillations during a successive ramp-and-hold temperature profile. These oscillations are expected to be a general phenomenon that should be observed under similar conditions of length, time, temperature, and mechanical properties of the bonded beams and adhesive. The calculated rate of temperature-dependent thermal bending was in good agreement with that measured on actual magnetic recording head gimbal assemblies. This is the first analysis that employs a viscoelastic adhesive model and the correspondence principle to describe slider crown phenomenon.
    Type of Medium: Electronic Resource
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