ISSN:
1432-1459
Keywords:
Wilson's disease
;
Positron emission tomography
;
Dopamine D2 receptor
;
Regional cerebral glucose metabolism
;
Functional recovery
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Regional cerebral glucose metabolism (rCMRGlc) and dopamine D2 receptor binding were measured in a 31-year-old, severely affected, untreated patient with Wilson's disease of 3 years' duration using positron emission tomography and18F-deoxyglucose and18F-methylspiperone ([18F]MSP), respectively. There was a severe reduction of striatal and extrastriatal rCMRGlc as well as of striatal [18F]MSP accumulation rate. After 1 year of treatment withd-penicillamine, striatal and extrastriatal rCMRGlc and striatal [18F]MSP accumulation rate reached almost normal levels. It is hypothesized that recovery of motor functions due to copper trapping therapy was associated with an increase in basal ganglia activity and a re-expression or upregulation of dopamine D2 receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00920620
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