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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 201-206 
    ISSN: 1432-1335
    Keywords: Intestinal metaplasia ; Gastric carcinoma N-Propyl-N′-nitro-N-nitrosoguanidine ; Wistar rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary PNNG, the propyl derivative of MNNG, was administered to Wistar rats at a concentration of 59.5 μg/ml in the drinking water for 4, 8, and 12 months and the rats were killed in the 15th month. Intestinal metaplasia was induced in the glandular stomachs of 25%, 75%, and 83% of the rats treated with PNNG for 4, 8, and 12 months, respectively. Metaplastic glands were found in the pyloric region, especially near the pyloric ring. These glands contained goblet cells and columnar cells with striated borders. No tumors were found in the stomach of rats after 4-months treatment, but adenomas were found after 8-months treatment, and both adenomas and adenocarcinomas after 12-months treatment.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 323-327 
    ISSN: 1432-1335
    Keywords: Croton oil ; Tumor promotion ; Gastrocarcinogenesis ; Wistar rat ; Crotonöls ; Tumor-Promotion ; Magencarcinogenese ; Wistar-Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die tumorfördernde Wirkung des Crotonöls für die Magencarcinogenese mit MNNG wurde an männlichen Wistar-Ratten untersucht. Bei fünf von 10 Ratten wurden Magencarcinome beobachtet, wobei zuerst während drei Monaten 83 μg/ml MNNG und dann 0.02% Crotonöl, gelöst in 0,5% Tween 60, neun Monate lang verabreicht wurden. Bei Ratten, die drei Monate lang mit MNNG und danach neun Monate lang mit Tween 60 allein behandelt wurden, sind keine Magencarcinome beobachtet worden. Das Auftreten von Magencarcinomen in diesen zwei Gruppen war demnach signifikant unterschiedlich (p〈0.05). Bei Ratten, denen nur Crotonöl mit Tween 60 verabreicht wurde, sind keine Geschwülste beobachtet worden.
    Notes: Summary The promoting effect of croton oil on gastrocarcinogenesis by MNNG was examined in male Wistar rats. Gastric carcinomas were found in five of 10 rats given 83 μg/ml MNNG for three months and then 0.02% croton oil with 0.5% Tween 60 as solvent for nine months. No gastric carcinomas were found in rats given MNNG for three months and then Tween 60 only for nine months. The incidence of gastric carcinomas in these two groups was significantly different (p〈0.05). No tumors were found in rats given only croton oil with Tween 60.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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