ISSN:
1476-5535
Schlagwort(e):
Mycotoxins
;
Aflatoxins
;
Aflatoxicosis
;
Syrian hamster
;
Reversal
;
Zinc
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
Notizen:
Summary Chronic exposure to aflatoxins (AFTs) below the LD50 can result in reduced weight gain, hepatocellular necrosis and bile duct cell proliferation. Here, we report whether dietary zinc (Zn2+) protects against both aflatoxicosis and precancer in male weanling hamsters fed either 14.6 mg/kg AFTs, 3000 mg/kg zinc carbonate, or both for 17 weeks. The AFTs (either alone or with Zn2+) reduced weight gains but not feed consumption. Whereas controls possessed 172.7±21.7 mg/100 ml plasma glucose, the AFTs and Zn2+ groups had 132.1±19.5 and 122.7 mg/100 ml, respectively. For plasma cholesterol, the AFTs plus Zn2+ group's was 26.5±4.3 compared to 32.3±3.0, 31.5±4.8 and 36.0±2.1 mg/100 ml for control, Zn2+ and AFTs groups, respectively. The latter exhibited bile duct cell hyperplasia, focal liver necrosis and hemorrhage but the AFTs plus Zn2+ group's livers had less damage. Meglahepatocytes indicated precancerous changes. These data suggest a trend toward Zn2+-induced reduction for AFTs-promoted liver damage.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01569410
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