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  • Zinc-finger protein  (1)
  • posterior chamber  (1)
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  • 1
    ISSN: 1432-1432
    Keywords: Zinc-finger protein ; Human ; Mouse ; Chromosome location ; Divergent evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We have isolated the human homologue of Mok2 gene encoding a Kriippel-like protein. The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH2-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2–q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International ophthalmology 19 (1995), S. 317-320 
    ISSN: 1573-2630
    Keywords: glaucoma ; posterior chamber ; uveitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract U.G.H. syndrome is a known complication of IOL implantation associated with the use of anterior and rarely, posterior chamber intraocular lenses. It is due to mechanical excoriation of the angle or iris by the haptics or optic of an IOL and consists of uveitis, glaucoma and hyphema (U.G.H.). The advised therapeutic approach is explantation of the IOL. Following implantation of a posterior chamber IOL, three patients presented with bleeding into the posterior chamber, one associated with glaucoma. No patient had signs of uveitis. We decided to adress the symptoms and not to explant the IOL. We believe that this constitutes a variant of the ‘classical’ U.G.H. syndrome, namely an incomplete posterior U.G.H. (I.P.U.G.H.) syndrome, in which explantation of the I.O.L. is not compulsory.
    Type of Medium: Electronic Resource
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