ISSN:
1432-1041
Keywords:
Talinolol
;
Sulfasalazine
;
β-adrenoceptor-blocking drugs
;
absorption
;
drug interaction
;
kinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The absorption of talinolol (TA) 50 mg was investigated without and together with the co-administration of sulfasalazine (SASP) 4 g in 11 healthy young volunteers, in order to clarify gastrointestinal transit of TA. Without SASP, the tmax of TA was 2.8 h, Cmax was 112 ng·ml−1 and the half life was 12 h; the AUCo-t was 958 ng·ml−1·h. In the case of concomitant administration of SASP, TA was found only in serum from 3 individuals, with a Cmax of 23 ng·ml−1 and a mean AUCo-t of 84 ng·ml−1·h. TA was not detectable in 5 subjects and it was at the limit of detection (2 ng·ml−1) in 3 subjects. Pharmacokinetic analysis was not possible in any of those individuals. The reason for the interaction appears to be the adsorption of TA by SASP. An interval of 2–3 h should elapse between giving SASP and other drugs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00280137
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