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  • 1
    Electronic Resource
    Electronic Resource
    Acid-induced esophagitis in cats is prevented by sucralfate but not synthetic prostaglandin E (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 217-224 
    Details
    ISSN: 1573-2568
    Keywords: esophagitis ; sucralfate ; prostaglandin ; cytoprotection ; acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cytoprotective effects of liquid sucralfate and a synthetic analog of prostaglandin E1 (PGE1) on acid-induced esophagitis in cats were studied. Esophagitis was induced in adult cats using a constant infusion of 0.1 N HCl at 1 ml/min for 20 min. Animals were infused for either one or three days. Mucosal lesions were evaluated by blinded investigators using both fiberoptic endoscopy and light microscopy. Histologic changes included basal cell hyperplasia, intraepithelial leukocytosis, and subepithelial leukocytosis. Liquid sucralfate given prior to acid infusion consistently prevented acid-induced lesions in both one- and three-day infusions, demonstrated by both endoscopy and quantitative histologic scoring. Indomethacin (200 μg/kg) given prior to sucralfate and acid did not affect sucralfate cytoprotection. Synthetic PGE1, given in doses of 5 μg/kg and 100 μg/kg, afforded no esophageal cytoprotection. These studies indicate that sucralfate is cytoprotective against acid-induced esophageal injury in cats, an effect that does not appear to be mediated by prostaglandin. In addition, synthetic PGE1 does not confer protection in this animal model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535736
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Software for teaching physiology and biophysics (1992)
    Springer
    Journal of science education and technology 1 (1992), S. 259-274 
    Details
    ISSN: 1573-1839
    Keywords: Educational software ; biophysics software ; physiological software ; bioengineering software ; Hodgkin-Huxley model software ; diffusion software ; single voltage-gated channel software
    Source: Springer Online Journal Archives 1860-2000
    Topics: Natural Sciences in General , Technology
    Notes: Abstract We describe a software library that we have developed to teach biophysics and physiology to undergraduate engineering and science students as well as to medical students. The library, which is under development, now includes software on: (1) the Hodgkin-Huxley model for excitation of action potentials in electrically excitable cells (such as nerve and muscle cells); (2) a random-walk model of diffusion; (3) single voltage-gated ion channels; (4) steady-state chemically mediated transport; and (5) macroscopic diffusion processes. The software is used in a variety of ways: as an integral part of lectures, as the basis of special sessions held in electronic classrooms, as a source of homework assignments, and for special projects defined by the students. We describe the software and some of the pedagogic methods we have used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00694407
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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