Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Controlled trial of high-dose octreotide in treatment of acute pancreatitis (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 644-647 
    Details
    ISSN: 1573-2568
    Keywords: octreotide ; acute pancreatitis ; treatment ; clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nineteen consecutive patients with acute pancreatitis were sequentially allocated to treatment with high-dose octreotide (N=9) or to act as controls (N=10). All other aspects of treatment were similar and were according to a strict treatment protocol. There was no significant difference between the two groups on admission with regard to recognized criteria of poor prognosis. The octreotide-treated group required significantly less analgesia and after 48 hr developed significantly fewer poor prognostic indicators, including falls in hematocrit of 〉10%, in serum albumin to 〈32 g/liter, and in serum calcium to 〈2.00 mmol/liter. Falls in arterial PO2 to 〈10 kPa, in serum albumin of 〉20%, and in hemoglobin of 〉2 g/dl were also significantly less frequent. There was a trend towards improvement in the octreotide-treated group in every other physiological and radiological indicator of disease severity. High-dose octreotide may reduce the severity of acute pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316794
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Cholecystokinin-8 induces edematous pancreatitis in dogs associated with short burst of trypsinogen activation (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 2152-2161 
    Details
    ISSN: 1573-2568
    Keywords: acute pancreatitis ; trypsinogen activation ; trypsinogen activation peptide ; pancreatic enzymes ; dogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study the early pathogenesis of acute edematous pancreatitis in dogs, we examined the relationship of pancreatic hyperstimulation with cholecystokinin-8 (10 μg/kg/hr intravenously for 6 hr) to alterations in circulating pancreatic enzymes and pancreatic morphology with special reference to trypsinogen activation. Cholecystokinin-8 infusion was associated with increases in plasma amylase, lipase, trypsin-like immunoreactivity, and plasma and urine trypsinogen activation peptide. Pancreatic parenchymal swelling and interlobular and subcapsular fluid accumulations were detected ultrasonographically within 2 hr of cholecystokinin-8. Circulating trypsin-like immunoreactivity and trypsinogen activation peptide in urine reached a peak at 2 and 4 hr, respectively, then declined despite progressive increases in circulating amylase and lipase and intrapancreatic fluid. No significant changes were observed in dogs receiving a saline infusion. This study illustrates that cholecystokinin-8 induces edematous pancreatitis in dogs that is associated with a short-lived burst of trypsinogen activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208999
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...