ISSN:
1573-8221
Keywords:
prothrombin
;
intermediate products 1 and 2
;
second anticlotting system
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Two components were isolated from the products of proteolysis of prothrombin by immobilized thrombin: intermediate product 1 (P1) which, under suitable conditions, can be transformed into thrombin, and product 2 (P2), which does not have this property. After intravenous injection of P1 into rats the total clotting time and the plasma recalcification time were lengthened. The total fibrinolytic activity (TFA) and the level of fibrinogen degradation products were raised, the fibrinogen concentration was lowered, and the degree of nonenzymic fibrinolysis and its contribution to TFA rose sharply. Mobilization of the anticoagulant and fibrinolytic potential of the body was due to the response of the second anticlotting system. Intravenous injection of P2 or prothrombin into rats did not stimulate this system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00799778
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