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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 6 (1973), S. 15-18 
    ISSN: 1432-1041
    Keywords: Warfarin ; ethyl biscoumacetate ; acenocoumarin ; phenindione ; fluoropindione ; albumin binding ; phenylbutazone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ethyl biscoumacetate and acenocoumarin are bound to the same sites on human albumin as warfarin. Phenindione and fluorophenindione are bound to other sites. Phenylbutazone inhibits binding of the former but has no effect on the latter. These results can account for the fact that clinical reports of interaction between phenylbutazone and vitamin K antagonists involve only coumarin drugs, especially warfarin, and not phenindione derivates.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 10 (1976), S. 139-145 
    ISSN: 1432-1041
    Keywords: Furosemide ; tolbutamide ; sulfafurazole ; sulfonamidochlorobenzoic acid ; protein binding ; albumin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The four sulphonamides studied — furosemide, tolbutamide, sulfafurazole and sulfonamidochlorobenzoic acid — bind to human albumin at the same sites but with decreasing affinity. These sites are also common to other drugs, namely acenocoumarin, chlorophenoxyisobutyric acid, phenylbutazone and warfarin. In plasma, the four sulphonamides considered bind mainly to albumin, but also, at higher concentrations, to globulins, to an extent that increases as their affinity for albumin lessens.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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