ISSN:
1432-1041
Keywords:
alpha2-adrenoceptor binding sites
;
oestradiol
;
yohimbine
;
intact platelets
;
healthy male volunteers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The specific binding (Bmax) of (3H-methyl)yohimbine to alpha2-adrenoceptor binding sites on intact platelets was increased by 43% in 6 out of 7 young male volunteers 4 days after a single i.m. injection of 10 mg sustained release oestradiol, and it had returned to the starting value 4 weeks after drug administration. Mean plasma oestradiol was 331 pg/ml on Day 4 and it was within the pre-treatment control range of 19 pg/ml 4 weeks after the injection. A close correlation between the post-injection plasma oestradiol concentration and the increase in alpha2-adrenoceptor binding sites on intact platelets was not found.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00544558
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