ISSN:
1436-2813
Keywords:
pulmonary edema
;
potassium concentration
;
osmolality
;
alveolar epithelium
;
lung transplantation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of hypothermia and hyperpotassium on alveolar fluid clearance in the resected human lung was examined by instilling an isosmotic albumin solution with a potassium concentration of 0.3 mEq/l or 20 mEq/l into one segment of a resected lobe within 10 min of surgical removal for bronchogenic carcinoma. The experiments were carried out at 37°C, 25°C, and 8°C over 4h, after which the alveolar fluid was aspirated. Alveolar fluid clearance was calculated by a simple equation using the changes in the albumin concentration of the alveolar fluid. It was found that although hypothermia at 8°C abolished alveolar fluid clearance completely, alveolar fluid clearance at 25°C was not different from that at 37°C. Moreover, although the potassium concentration increased in the alveolar fluid at 37°C and 8°C, hyperpotassium did not affect the alveolar fluid clearance. These findings indicate that the net transport of potassium leans to influx from the alveolar epithelial cells into the alveolar spaces when the alveolar potassium concentration is low, and to efflux from the alveolar spaces when the alveolar potassium concentration is high. Thus, we conclude that hypothermia abolishes alveolar fluid clearance in resected human lungs, but that the potassium concentration in alveolar fluid does not affect alveolar fluid clearance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00311485
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