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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 91 (1989), S. 85-90 
    ISSN: 1573-4919
    Keywords: liposome ; aspergillosis ; mannose ; amphotericin-B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The efficacy and toxicity of free and liposome intercalated amphotericin-B (Amp-B) in controlling Aspergillosis, caused byAspergillus fumigatus in BALB/c mice were studied. Liposomal Amp-B had higher LD50 (8.1 mg/kg) as compared to that of the free drug (1.2 mg/kg). An improvement in the therapeutic index of the drug was observed with liposomal formulation of the drug. We also focussed on the effect of lipid composition and surface sugar in modulating the therapeutic potency of Amp-B. The most effective liposomal preparation was composed of egg phosphatidylcholine (EPC) : L-α-phosphatidylethanolamine, dipalmitoyl (DPPE): cholesterol (Chol) in the molar ratio of 6:1:3. Amp-B intercalated into mannose grafted liposomes (LD50 = 9.3 mg/kg) was more effective as compared to the other formulation tested.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2932
    Keywords: rain event ; pH ; intensity ; crustal ; antecedent periods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Rain water samples of equal volume (50 mL) were collected from two couvective showers at New Delhi on 28 July and 23 August during the monsoon, 1994. The variation of constituents of both the showers showed different trends which might have been due to different antecedent periods. The first shower occurred after an antecedent period of 2–3 hours while the second shower occurred after a 14 day interval. The first shower had acidic pH (〈5.6) and relatively higher concentration of NH4, SO4, NO3, Cl, F and K indicating insignificant below cloud scavenging. The second shower had alkaline pH (〉5.6) and relatively higher concentrations of Ca and Mg. The higher concentration of Ca and Mg in the second shower were due to the loading with particulate matter during the preceding 14 days which made below cloud scavenging significant.
    Type of Medium: Electronic Resource
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