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  • 1
    Electronic Resource
    Electronic Resource
    T-Type Calcium Channel Blockade in the Management of Chronic Ischemic Heart Disease (2000)
    Springer
    Cardiovascular drugs and therapy 14 (2000), S. 459-461 
    Details
    ISSN: 1573-7241
    Keywords: angina pectoris ; calcium channel ; Mibefradil ; T-Type channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The T-Type calcium channel offers a new therapeutic target for teatment of patients with cardiovascular disease. Mibefradil, a T channel blocker, produces heart rate slowing and coronary vasodilatation but without the negative inotropic effect commonly seen when L-Type channel blockers are used. The present study shows Mibefradil prevents ischemic episodes that are and are not preceded by an increase in heart rate. Although Mibefradil has been withdrawn because of multiple drug interactions, new T-Type calcium channel blockers are under development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007820919574
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