ISSN:
1573-7241
Keywords:
angiotensin
;
vascular smooth muscle
;
hypertension
;
converting enzyme inhibitors
;
hypertrophy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The pathogenesis of hypertension is associated with a remodeling of vascular structure. Folkow has postulated that the decreased luminal area and thickened medial layer in hypertensive vessels enhances the vasoconstrictive response to vasoactive agents. It is hypothesized that this increase in vascular reactivity may serve to perpetuate hypertension. A growing body of evidence suggests that autocrineparacrine vasoactive substances and growth factors modulate vascular structure in hypertension. We speculate that therapeutic interventions that normalize blood pressure as well as reverse the vascular remodeling process may have special clinical value. The role of the paracrine renin-angiotensin system and angiotensin converting enzyme inhibitors in hypertension is discussed in this context.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01857638
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