ISSN:
1572-8951
Keywords:
Review
;
polyoxometalate
;
transition metal substituted polyoxometalate
;
homogeneous catalysis
;
oxygenation of organic substrates
;
anti-HIV activity
;
toxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract This review concentrates on two areas of intense research interest involving polyoxometalates, homogeneous catalysis and medicine. The discussion of homogeneous catalysis covers a brief historical overview of organic substrate oxidation, oxidant desirability, and other classes of oxidation catalysts. The principal focus of the catalysis, use of oxidatively resistant d-electron-transition-metal-substituted polyoxometalates (TMSP) for sustained oxygenation of organic substrates, is then examined. A general compilation is given in Table I of the literature reactions involving 21 TMSP complexes, 10 oxidants, five classes of substrates, and 10 solvent systems. Possible extensions of this chemistry are discussed. The discussion of polyoxometalates in anti-HIV chemotherapy includes brief historical background of this rapidly developing area followed by an evaluation of the effectiveness of polyoxometalates as anti-HIV agents. Over two hundred polyoxometalates have been examined in cell culture with the activities (EC50 values) and toxicities (IC50 values) listed in Table II. Polyoxotungstates as a class of polyoxometalates show the most promise with respectable levels of activity, selectivity, and low toxicity. The effect of polyoxometalate countercation and modes of HIV inhibition are discussed. The review contains 60 references.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00999637
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