ISSN:
1573-5117
Keywords:
arachidonic acid derivatives
;
caribbean
;
eicosanoids
;
eicosapentaenoic acid derivatives
;
Oregon
;
seaweed
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Red marine algae are shown in this work to be a rich source of eicosanoid-type natural products. This is the first isolation of several of these mammalian arachidonic acid metabolites from any marine or terrestrial plant source (12-HETE, 12-HEPE, 6(E)-LTB4, hepoxilin B3). A few of these represent truly novel substances never previously isolated from nature [12(R), 13(S)-diHETE]. Inherent in these seaweed natural product structures is evidence for a highly evolved lipoxygenase-type metabolism that matches or exceeds the complexity of comparable metabolic routes in mammalian systems. As these compounds are produced by algae in relatively large quantities (0.1–5.0% of crude lipid extracts), these plants could be important commercial resources for these expensive and rare biochemicals. Further, we suggest that this metabolism is important to physiological processes in red algae that are completely unknown at present. For example, it is possible that they act in an exocrine sense to coordinate reproductive events, a hypothesis under current investigation through culture studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00040297
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