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  • augmentation of host resistance to infections  (1)
  • excretion  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Disposition of125I-labeled recombinant human tumor necrosis factor in the tumor-bearing mouse (1989)
    Springer
    Biotherapy 1 (1989), S. 7-18 
    Details
    ISSN: 1573-8280
    Keywords: disposition ; distribution ; excretion ; Meth A sarcoma ; pharmacokinetics ; tumornecrosis factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Disposition of [125I]rHu-TNF was elucidated in BALB/c mice bearing Meth A fibrosarcoma 7 days after transplantation. Afteri.v. administration, [125I]rHu-TNF measured by radioactivity and immunoreactivity biphasically decreased in plasma. Tumor level of [125I]rHu-TNF was the maximum at 1 h, then decreased and finally remained essentially constant. After i.t. administration, plasma level reached the maximum at 1 h. Tumor level decreased quickly and then became essentially constant. [125I]rHu-TNF was suggested to be degraded to small fragments in the tumor. Significant distribution of [125I]rHu-TNF was found in the kidney, lung, liver and tumor. Most tissue levels decreased with time in parallel with plasma levels. [125I]rHu-TNF radioactivity was found in proximal convoluted tubules of kidney and in those areas of tumor consisting of degenerating cells with pyknotic nuclei. Urine contained most of administered radioactivity, which being neither immunoreactive nor protein-bound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02170131
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interleukin-1α: Its possible roles in cancer therapy (1989)
    Springer
    Biotherapy 1 (1989), S. 327-338 
    Details
    ISSN: 1573-8280
    Keywords: antitumor activity ; augmentation of host resistance to infections ; cancer therapy ; myelorestorative activity ; recombinant interleukin-1α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our studies on recombinant human IL-1α polypeptide were summarized with respect to molecular cloning, production, quantitative assay systems, antitumor activity, myelorestorative activity and augmentation of host resistance to infections. Recombinant human IL-1α (18 kDa) was produced through the expression of the cloned human IL-1α cDNA inEscherichia coli and purified to an endotoxin-free homogeneous polypeptide. The human IL-1α inhibited dose-dependently the growth of syngeneic murine tumors transplanted in mice and completely regressed the tumors in some cases, and its antitumor activity was significantly enhanced in combination with indomethacin. The human IL-1α accelerated the recovery of the numbers of peripheral leukocytes and neutrophils in a dose-dependent manner at a dose as low as 10 ng/mouse/day in myelo suppressed mouse model produced by administering anticancer chemotherapeutic drugs. The myelorestorative effect of IL-1α was observed not only on leukocytes/neutrophils, but also on platelets in myelosuppressed mice. In addition, the human IL-1α markedly augmented dose-dependently resistance of normal and leukopenic mice to various microbial infections. These results suggested that recombinant human IL-1α might be useful for cancer therapy from the viewpoints of improving adverse effects such as myelosuppression caused by chemotherapy and/or radiation therapy and preventing infections. In addition, use of IL-1α may permit more intensive chemo- and radiation therapies using higher doses. Finally, the antitumor activity of the IL-1α itself may play an important role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02171009
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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