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  • 1
    Electronic Resource
    Electronic Resource
    HLA antigens and intracranial aneurysms (1992)
    Springer
    Acta neurochirurgica 116 (1992), S. 1-5 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial aneurysm ; HLA complex ; auto-immunoaggression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The frequencies of the HLA-A, -B and -DR were determined in a group of 59 transplant donors who died from subarachnoid haemorrhage within three days following the rupture of intracranial aneurysm (the SAH group) and compared with those of a control group consisting of 389 donors who died from other causes. The only significant difference was in the increased frequency in the SAH group of non-typed (“empty”) -DR loci in association with the DR7 phenotype. The most probable explanation of this finding is that in the SAH group the frequency of DR7 homozygotes is several times higher than in the general population, and that bearing the DR7 allele in homozygotic form is associated with a very high risk of developing potentially fatal intracranial aneurysmal haemorrhage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541246
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Impaired in vitro proliferative response of suppressor lymphocytes in patients with subarachnoid haemorrhage from ruptured intracranial aneurysm (1993)
    Springer
    Acta neurochirurgica 122 (1993), S. 240-243 
    Details
    ISSN: 0942-0940
    Keywords: SAH ; immunology ; mitogenic response of lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Proliferative response to mitogens concanavalin A, phytohaemoagglutinin and pokeweed mitogen, and other chosen indicators of the activity of the immune system were assayed in peripheral blood mononuclear cells isolated from blood of patients with subarachnoid haemorrhage from ruptured aneurysm. Healthy blood donors served as control group. The SAH group displayed impaired response to concanavalin A, which is a mitogen specific for suppressor cells. It is suggested that the impaired activity of suppressor cells pre-existed in patients with subarachnoid haemorrhage, and after intracranial bleeding it might have contributed to the development of late neurological deficits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405536
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits (1991)
    Springer
    Acta neurochirurgica 108 (1991), S. 81-84 
    Details
    ISSN: 0942-0940
    Keywords: SAH ; immunology ; angiopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study deals with the effects of immunomodulators on the morphology of intracerebral arterial walls in rabbits with experimental subarachnoid haemorrhage (SAH). Immunostimulators: thymostimuline and inosine dimethylamino-isopropanol-p-acetamido-benzoate were found to aggravate the angiopathic changes, whereas immunosuppressive drugs — cyclosporine A and azathioprine appeared to prevent the damage. The authors consider the possibility of using immunosuppressive drugs in patients with ruptured intracranial aneurysms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407672
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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