ISSN:
1432-2013
Keywords:
calcium
;
erythrocyte
;
bacterial toxin
;
Vibrio parahaemolyticus
;
Ca2+- activated K+ channel
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Vibrio parahaemolyticus secretes an exotoxin prepared as Kanagawa haemolysin (KH) which causes marked alterations to the function of epithelial, cardiac and other cell types, but whose cellular mode of action is poorly understood. Using human red cells as a model system with radiotracer flux techniques, we have shown that KH (1) markedly elevated the basal leak to K+, (2) raised Ca2+ influx, and as a consequence of this, (3) stimulated the Ca2+-activated K+ channel. These results suggest that an important deleterious effect of this toxin is to elevate cation permeability, which will have both direct and indirect actions on the behaviour of a variety of cell typesin vivo.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02191918
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