Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Antagonistic effect of bicuculline and thiosemicarbazide on the tranquilizing action of diazepam (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 332-334 
    Details
    ISSN: 1573-8221
    Keywords: diazepam ; bicuculline ; γ-aminobutyric acid ; thiosemicarbazide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Bicuculline, a specific blocking agent of GABA-ergic receptors, in doses of 0.5 and 1 mg/kg (subcutaneously); and thiosemicarbazide, which inhibits GABA (γ-aminobutyric acid) synthesis in the brain, in doses of 5 and 8 mg/kg (subcutaneously); are antagonists of diazepam and weaken its tranquilizing action during conflict behavior in experimental rats. Bicuculline exhibits stronger antagonism toward diazepam than thiosemicarbazide. The results are evidence that GABA-ergic mechanisms may participate in the tranquilizing action of the benzodiazepines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799353
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Role of cholinergic mechanisms in the mechanism of action of bicuculline (1978)
    Springer
    Bulletin of experimental biology and medicine 86 (1978), S. 1048-1050 
    Details
    ISSN: 1573-8221
    Keywords: bicuculline ; cholinergic mechanisms ; GABA ; convulsions ; recovery cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The hypothesis of a possible role of cholinergic structures in the mechanism of the action of bicuculline was tested by screening and electrophysiological methods. Neither muscarinic (M-) nor nicotinic (N-) cholinolytics (benactyzine, atropine, aprophen,* and pediphen†) abolished convulsions produced in mice by bicuculline. Meanwhile substances inducing the accumulation of γ-aminobutyric acid (GABA) in the brain, such as aminohydroxyacetic acid (AHAA) and depakine, had a well marked protective action against bicuculline convulsions. The electrophysiological experiments also showed that the M-cholinolytic benactyzine does not abolish the effects of bicuculline. Bicuculline was shown to reduce the depression of the test response in the recovery cycle of the primary response of the rat sensomotor cortex when intervals between stimuli measured 40–125 msec, whereas benactyzine reduced the late facilitation of the test response when intervals between stimuli measured 150–300 msec. No interaction could be found between benactyzine and bicuculline by this test. It was concluded from these results that the effects of bicuculline are produced by blockade of postsynaptic GABA receptors and are not connected with the activity of cholinergic structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799587
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Antagonism of RO 15-1788 with benzodiazepines with respect to effect on motivated aggression and analgesic action (1985)
    Springer
    Bulletin of experimental biology and medicine 99 (1985), S. 471-474 
    Details
    ISSN: 1573-8221
    Keywords: GABA interaction ; benzodiazepines ; opiates ; RO 15-1788, an antagonist of benzodiazepine receptors ; bicuculline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00842743
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effect of GABA-ergic agents on the analgesic effect of morphine in rats (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 711-714 
    Details
    ISSN: 1573-8221
    Keywords: GABA ; morphine ; cyclic nucleotides ; opiate receptors ; bicuculline ; thiosemicarbazide ; analgesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In order to detect possible interaction between GABA and opiates, the effects of GABA-ergic drugs on analgesia induced by morphine were studied. The vocalization response to electrical stimulation of the tail in rats was used as an index of the action of morphine. Thiosemicarbazide, an inhibitor of glutamate decarboxylase, and bicuculline, which blocks GABA-ergic receptors, drugs which, it is suggested, can be considered as a group of GABA-negative compounds, weaken and shorten the effect of morphine. Depakine, an inhibitor of α-ketoglutarate-GABA-transaminase, like GABA itself, given in large doses (GABA-positive effects) strengthens morphine analgesia and prolongs its effect. The possible causes of these relations between GABA and opiates are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00804772
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...