ISSN:
1573-7373
Keywords:
experimental brain tumor
;
autoradiography
;
induced hypertension
;
blood flow
;
capillary permeability
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To study the possibility of enhancing the delivery of antineoplastic agents to tumor tissue, we conducted an experimental study using induced hypertension with angiotensin 11 in rats with experimental brain tumors. Drug delivery was evaluated by measuring local cerebral blood flow (LCBF) and regional cerebral capillary permeability with quantitative autoradiography. There was no significant difference of LCBF in the central region of tumor tissue between the control group and the induced hypertension group. LCBF in the peripheral region of tumor tissue in the induced hypertension group was significantly higher than that in the control group. On the other hand, despite induced hypertension, no significant changes in the regional cerebral capillary permeability were observed between the groups. These results indicate that delivery of the lipid-soluble antineoplastic agents, which depend upon cerebral blood flow, can be enhanced by induced hypertension.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00177533
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