ISSN:
1432-1041
Keywords:
Clonidine
;
tiamenidine
;
salivary flow
;
blood pressure
;
sedation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary An established method for collecting uncontaminated parotid saliva has been applied to assessment of salivary flow rate. Following single doses of 0.3 mg clonidine and 1.0 mg tiamenidine (HOE 440) changes in blood pressure, heart rate, sedation (assessed by a self-rating scale) and salivary flow were followed in nine normal subjects. Both drugs produced a fall in systolic and diastolic blood pressure, sedation, depression of salivary flow and a lowering of heart rate. These changes were maximal between 2 and 6 h and were more marked after clonidine than after timenidine. As tiamenidine 1.0 mg did not produce a hypotensive effect equivalent to clonidine 0.3 mg direct comparison of side-effects attributable to these agents proved difficult. The evidence suggests, however, that tiamenidine would cause sedation and reduction in salivary flow comparable to clonidine if given in an equivalent hypotensive dose.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00560455
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