ISSN:
1573-8221
Keywords:
chemical desympathization
;
blood pressure
;
neurofibrils
;
tyramine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The number of cells in the sympathetic ganglia of rats was reduced by means of guanethidine to 30% (group 1) and to 1% (group 2) of normal. In rats aged 2 months pressor responses to asphyxia and to stimulation of the femoral nerve were absent. In the animals of group 1 (but not of group 2) recovery of the reflexes was observed at the age of 4 months. An increase in the number of neurofibrils was demonstrated in the neurons surviving guanethidine treatment, indicating growth of the axon of these cells. Investigation of responses to the indirect sympathomimetic tyramine revealed an increase in the number of effector sympathetic endings at the periphery at the age of 4 months in the animals of group 1. It is suggested that restoration of reflex responses in the animals of this group at the age of 4 months took place on account of growth and branching of the axons of the surviving nerve cells, as a result of which the density of the effector innervation at the periphery was restored.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00786410
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