ISSN:
1573-7217
Keywords:
breast cancer
;
chemotherapy
;
cisplatin/5-fluorouracil synergism
;
salvage therapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 24 patients with a median of 3 prior chemotherapy regimens were treated in our department with cisplatin 20 mg/m2 (with pre- and posthydration) and 5-fluorouracil 200 mg/m2 i.v. on day 1–5, every three weeks. 23 patients are evaluable; one had early death. 4 patients (17%) achieved a partial response, 8 had stable disease, and 11 progressed. Toxicity observed was moderate and no renal toxicity was noted. This study therefore shows tolerable toxicity but limited usefulness of adding cisplatin to 5-fluorouracil according to this schedule in these highly pretreated patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01807286
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