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  • 1
    Electronic Resource
    Electronic Resource
    A multicenter validation study of sentinel lymph node biopsy by the Japanese Breast Cancer Society (2000)
    Springer
    Breast cancer research and treatment 63 (2000), S. 31-40 
    Details
    ISSN: 1573-7217
    Keywords: axillary lymph node dissection ; breast cancer ; sentinel lymph node biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several pilot studies have indicated that SLN biopsy can be used to identify axillary lymph node metastases in patients with breast cancer. To confirm this finding, a multicenter study in a variety of practice settings was performed. A total of 674 patients with breast cancer at five institutions were enrolled. The techniques of SLN identification included the vital dye-guided and the vital dye- and gamma probe-guided methods. The SLN was removed, and complete axillary lymph node dissection (ALND) was performed. SLN and ALND specimens were examined separately. The SLN was successfully identified in 214 (94%) of 227 patients using the combined dye- and gamma probe-guided methods. The SLN was identified in 332 (74%) of 447 patients using vital dye-guided method alone. Patient age of at least 51 years, medially located primary tumor, and clinically positive nodes were correlated with failure to identify the SLN. The accuracy of SLN biopsy for the detection of metastatic disease was 96% (522 of 546), and the sensitivity was 90% (203 of 226). Accuracy of 100% was achieved in the patients with tumors less than 1.6 cm in diameter. All 23 false negative results occurred with larger primary tumors. SLN biopsy can accurately predict the presence or absence of axillary lymph node metastases, particularly in patients with small (≤ 1.5 cm) breast cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006428105579
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of estrogen metabolism on proliferation of human breast cancer (1997)
    Springer
    Breast cancer research and treatment 42 (1997), S. 57-64 
    Details
    ISSN: 1573-7217
    Keywords: estrogen metabolism ; breast cancer ; catecholestrogen ; estrone sulfatase ; noncancerous tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the influence of estrogenmetabolism on human breast cancer, estradiol 2- and16α-hydroxylase (2- and 16α-OHase) activities were determined inthe microsomal fractions of cancer tissues by usingreverse phase HPLC. 2-OHase activity was detected inmost cancer tissues and noncancerous tissues, but theactivity was significantly lower in cancer tissues thanin the paired noncancerous tissues (0.01 〈 p〈 0.02). Interestingly the patients without lymph nodemetastasis had significantly higher 2-OHase activity in cancertissues than those with lymph node metastasis (0.02〈 p 〈 0.05). No correlation was observedbetween ER status and 2-OHase activity in cancertissues. On the other hand, 16α-OHase activity wasdetected only in one third of the breastcancer tissues examined. The activity was not significantlydifferent from that in noncancerous tissues, although itwas relatively higher in ER-positive cancer tissues whencompared with that in ER-negative ones (0.05 〈p 〈 0.1). Estrone sulfatase activity measured simultaneouslyin the cytosol fractions of some specimens wasmuch higher in cancer tissues than in noncanceroustissues (0.02 〈 p 〈 0.05). We found,however, no correlation between estrone sulfatase activity andestradiol hydroxylase activity. Taken together, our results suggestthat the increase in 2-OHase activity prevents theproliferation of breast cancer and that estradiol metabolismis regulated independently of the local biosynthesis ofestrogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:BREA.0000010495.08233.09
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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