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  • breast cancer screening  (1)
  • odds ratio  (1)
  • 1
    ISSN: 1573-7217
    Keywords: breast cancer screening ; cost‐effectiveness ; double reading ; mammography screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Double reading is a widely used criterion standard in breast cancer screening despite a lack of evidence of the cost‐effectiveness of the second reading. This study evaluates the incremental cost‐effectiveness of such a strategy. Design. Cost‐effectiveness analysis: Nationwide population‐based semi‐annual screening program for women aged 50–59 in Finland. Participation rate was 91%. All mammograms (95,423) performed during 1990–1995 in three screening centers of the Finnish Cancer Society were read by two radiologists with gradings recorded. The effectiveness of the double reading was the difference in cancers detected in the double compared to that of the single reading. Incremental costs of the double reading for the health care and non‐health care and the time costs were estimated. The main outcome measure was the incremental cost per additional cancer found as a result of the double‐reading strategy. Results. The total number of cancers detected with the double and single reading were 290 and 261, respectively. A significantly higher ratio of carcinoma in situ was the causative pathology in cancers detected only by the second reader. The cost per cancer detected with a single reading was US$ 18,340. The incremental cost of any additional cancer found was US$ 25,523, that is, a 39% higher cost per additional cancer found by double reading. Conclusions. The additional cost per cancer detected by double reading is not drastically higher than with single reading. However, the additional cost per life year saved may be much higher.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Breast cancer research and treatment 57 (1999), S. 165-173 
    ISSN: 1573-7217
    Keywords: follow‐up ; mammographic pattern ; odds ratio ; Wolfe's classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of the study was to estimate the incidence of unfavourable mammographic pattern by risk factors of breast cancers. Data consisted of 1890 Finnish women with mammographic pattern of either N1 or P1 (Wolfe's classification) at the initial screening. The screening was repeated every second year from 1982 to 1990 and at each screening round the mammographic pattern was assessed. The incidence rate of P2,DY pattern was 1.9/100 woman years. The incidence of P2,DY pattern was significantly related to age. The age‐adjusted odds ratio (OR) (based on logistic regression) was 2.0 (95 CI 1.0–3.9) among women with hormonal replacement therapy (HRT), 0.6 (95 CI 0.4–0.9) among postmenopausal women, 0.2 (95 CI 0.1–0.4) among women with large breasts and 0.2 (95 CI 0.1–0.3) among women with large body mass index (BMI). After multivariate adjustment by logistic regression only the effect of BMI remained statistically significant, odds ratio of P2,DY pattern for women with BMI 25 or more was 0.2 (95 CI 0.1–0.6) compared to women with BMI less than 20.
    Type of Medium: Electronic Resource
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