ISSN:
1432-2013
Schlagwort(e):
cGMP
;
cGMP-dependent protein kinase
;
Cyclie nucleotides in skinned smooth muscle
;
Skinned guinea pig taenia coli
;
Skinned chicken gizzard
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract The effect of cGMP and cGMP-dependent protein kinase (cG-PK) on contraction and relaxation was studied in skinned smooth muscle fibers from guinea pig taenia coli and chicken gizzard. At a fixed [Ca2+] relaxation was significantly enhanced by activated cG-PK in fibers from guinea pig taenia coli, but not in those from chicken gizzard. The Ca2+-requirement for half maximal tension maintenance was shifted to the right. Relaxation was associated with a decline in phosphorylated myosin light chain-2 from 34% to 25%. Similarly to relaxation activated cG-PK inhibited tension development only in fibers from taenia coli. These results suggest that mammalian and chicken smooth muscle fibers respond differently to cG-PK.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00580726
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