ISSN:
1569-8041
Keywords:
hyponatremia
;
inappropriate ADH syndrome
;
review
;
small-cell-lung carcinoma
;
tumour lysis syndrome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A patient with a small-cell lung cancer (SCLC) developed an asymptomatichyponatremia, with all features of the syndrome of inappropriate antidiuretichormone secretion (SIADH), two days after the start of his first cycle ofchemotherapy with vindesine, ifosfamide and cisplatin. Progression of thetumour with an increase in paraneoplastic SIADH, or drug-induced causes ofhyponatremia, could be ruled out by his further clinical course. The event wasinterpreted as a consequence of ADH release during the initial tumour celllysis after effective chemotherapy. The occurrence of hyponatremia during the initial phase of chemotherapy forSCLC should be interpreted with caution. Although it is most commonly due toan increase in paraneoplastic ADH secretion reflecting ineffective therapy,it can also be due to release of ADH from malignant cells in the period ofrapid tumour lysis, reflecting effective therapy. Based on this rare occurrence, a review of the aetiology, clinicalfindings, diagnosis, prognosis and treatment of SIADH in general is presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008369932384
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