ISSN:
1573-4986
Schlagwort(e):
heparin biosynthesis
;
carbohydrates
;
sulfated disaccharides
;
synthesis
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract The synthesis of the disaccharides methyl 4-O-(2′/3′-O-sulfo-β-d-glucopyranosyluronic acid)-2-amino-2-deoxy-α-d-glucopyranoside3 and4 as, disodium salts is described. Allyl 4,6-O-benzylidene-α-d-glucopyranoside6 was converted to trichloroacetimidate20 Glycosylation of20 with5 promoted by BF3·OEt2 gave disaccharide21. Deacetylation of21 followed by monoacetylation of the resultant diol22 afforded the two monoacetylated disaccharides23 and24. Sulfation and deprotection of each disaccharide gave the desired sulfated compounds3 and4.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01053195
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