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  • 1
    Electronic Resource
    Electronic Resource
    Cellular mechanisms of hypertrophic cardiomyopathy in spontaneously hypertensive rats (SHR) (1994)
    Springer
    Bulletin of experimental biology and medicine 117 (1994), S. 96-99 
    Details
    ISSN: 1573-8221
    Keywords: cardiomyocytes ; hypertrophy ; spontaneously hypertensive rats (SHR) ; cell population size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract It is shown that the weight dynamics of the body, heart and left ventricular myocardium is similar in Wister rats and SHR, but the number of cardiomyocytes in the 5th and 24th weeks of postnatal development is considerably higher in Wistar rats than in SHR. The earlier maturation of cardiomyocytes in SHR rats leads to their reduced proliferative activity, thus blocking the growth of the cell population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02444092
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of repeated complete starvation on quantitative parameters of rat cardiomyocytes (1994)
    Springer
    Bulletin of experimental biology and medicine 117 (1994), S. 665-668 
    Details
    ISSN: 1573-8221
    Keywords: starvation period ; rat myocardium ; cardiomyocytes ; cell population
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Sixty-four male Wistar rats were subjected to repeated complete starvation with free access to water. Each starvation period lasted 6 days and was followed by a 7-day recovery period. The concentration of cardiomyocytes (CMC) and their total number in the left ventricle (LV) were measured after alkaline dissociation of the myocardium. The volume density of muscle fibers and their absolute total mass in the LV were determined by stereological analysis. It is shown that after 6 successive starvation periods the proliferative potential of the CMC population is reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02444350
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Peculiarities of Intracellular Regeneration of Cardiomyocytes during Plastic Myocardial Insufficiency (2000)
    Springer
    Bulletin of experimental biology and medicine 130 (2000), S. 1011-1016 
    Details
    ISSN: 1573-8221
    Keywords: anthracycline cardiomyopathy ; SHR rats ; plastic myocardial insufficiency ; cardiomyocytes ; intracellular regeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We performed morphological assay of the myocardium in Wistar rats with anthracycline cardiomyopathy and SHR rats with genetically determined arterial hypertension causing hypertrophic cardiomyopathy. Both disorders were accompanied by a decrease in protein synthesis and development of plastic cardiomyocyte insufficiency. Electron microscopy revealed peculiarities of intracellular regeneration of cardiomyocytes. We observed disorientation of newly formed myofibrils lying between preserved myofibrils. These myofibrils were positioned perpendicular or at angle to the long axis of muscle fibers, or extended from the Z line (in a fan-like manner) crossing each other. Regeneration disturbances also included excessive elongation of myofibrils. These abnormalities of myofibril regeneration were related to changes in transcription and translation in cardiomyocytes, due to DNA damages caused by cardiotoxic doses of rubomycin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1002886428718
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Apoptosis of Cardiomyocytes as Extreme Manifestation of Regeneration and Plastic Insufficiency of Myocardium (2000)
    Springer
    Bulletin of experimental biology and medicine 130 (2000), S. 903-907 
    Details
    ISSN: 1573-8221
    Keywords: anthracycline cardiomyopathy ; regeneration and plastic myocardium insufficiency ; cardiomyocytes ; absolute number of cardiomyocytes ; apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Alkaline dissociation of the myocardium from rats with modeled anthracycline cardiomyopathy revealed decreased absolute number of cardiomyocytes, disturbances in their intracellular regeneration, although no sings of necrosis were observed. Regeneration and plastic insufficiency of the myocardium due to structural changes in the nuclei and disturbances in myofibril reproduction resulting from selective suppression of synthesis of contractile proteins in the cardiomyocytes leads to the death of up to 30% cardiomyocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015386800781
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    Paper (German National Licenses)
    Fulltext
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