ISSN:
1573-8221
Keywords:
catecholamines and serotonin in the brain and blood
;
neuroallergy
;
monoamine oxidase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The concentration of serotonin (ST), noradrenalin, and adrenalin in the blood, cerebrospinal fluid, and certain brain structures and the monoamine oxidase (MAO) activity were investigated in the course of experimental allergic encephalomyelitis in dogs. In the preparalytic period a tendency was observed for the ST concentration to fall and the catecholamine concentration to rise. The stage of clinical manifestations of encephalomyelitis was accompanied by lowering of the ST level in the white matter of the hemispheres and by generalized inhibition of adrenergic structures. No significant change in MAO activity was found, so that a disturbance of the biosynthesis of monoamines as a result of immune aggression could be the possible cause of inhibition of the monoaminergic system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00786430
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