ISSN:
1432-1335
Keywords:
Antineoplastic phospholipids
;
U937 cells
;
cell differentiation
;
histone H10
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The proliferation of the human promonocytic leukemia cell line U937 is inhibited by several ether lipids, ether lipid analogues and by phorbol esters. An early effect of this retardation of cell growth is the induction of a basic chromosomal protein, histone H10. Northern blot analysis of H10 mRNA levels reveals an increase of the mRNA concentration within a few hours after addition of hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. This early effect on the synthesis of a subtype of H1 proteins precedes the expression of several parameters of the monocytic differentiation of U937 cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01612994
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